Deep second-degree burns are characterized by delayed formation of granulation tissue and impaired angiogenesis. Erythropoietin\n(EPO) is able to stimulate angiogenesis and mitosis, activating vascularization and cell cycle.The aim of our study was to investigate\nwhether two biosimilar recombinant human erythropoietins, EPO-? and EPO-?,may promote these processes in an experimental\nmodel of burn injury. A total of 84 mice were used and a scald burn was produced on the back after shaving, in 80?C water\nfor 10 seconds. Mice were then randomized to receive EPO-? (400 units/kg/day/sc) or EPO-? (400 units/kg/day/sc) or their\nvehicle (100 �µL/day/sc 0.9% NaCl solution). After 12 days, both EPO- and EPO-? increased VEGF protein expression. EPO-Z\ncaused an increased cyclin D1/CDK6 and cyclin E/CDK2 expression compared with vehicle and EPO-Z (P < 0.001). Our study\nshowed that EPO-? and EPO-? accelerated wound closure and angiogenesis; however EPO-? resulted more effectively in achieving\ncomplete skin regeneration. Our data suggest that EPO-Z and EPO-? are not biosimilars for the wound healing effects. The higher\nefficacy of EPO-? might be likely due to its different conformational structure leading to a more efficient cell proliferation and skin\nremodelling.
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